

Learn How To Prevent Alzheimer's Disease Through Lifestyle and Genetics?
Alzheimer’s disease is known to be a progressive brain disorder which shall slowly destroys memory and thinking skills. This can eventually lead to the inability for carrying out simple tasks.
This condition of forgetting to carry out simple chores is the most common cause of dementia. It is a general term for memory loss and other cognitive abilities that are serious enough to interfere with daily life.
While there is absolutely no guaranteed way to prevent Alzheimer’s, there are various research that strongly do suggests with a combination of lifestyle choices. They also understand your genetic predisposition as it can significantly lower those risk.
The Growing Challenge of Alzheimer's Disease
The disease of Alzheimer’s poses a significant global health challenge. In 2019, India alone was well estimated to have approx. 3.69 million active cases of Alzheimer’s and other dementias. This goes well with a prevalence rate of approximately. 4.3%.
Further the Projection also suggests that by 2050, the number of dementia cases might globally see as a staggering 166% increase. This can reach around 152.8 million individuals.
India is expected to be the country with the second-largest number of dementia cases post China by 2050. This rising burden can highlight the urgent need for awareness and proactive measures.
Understanding the Roots of Alzheimer's Disease
While the exact causes of Alzheimer’s disease are still being researched, it is quite well understood to be a complex interplay of genetic, lifestyle, and environmental factors. Beta-amyloid plaques and tau tangles are the hallmarks of the disease in the brain. It disrupts communication that lies between brain cells and can further lead to death in extreme cases.
Modifiable Risk Factors: Taking Control of The Brain Health
While age and family history are non-modifiable risk factors, there is a significant portion of Alzheimer’s risk that is well linked to factors that can influence. Focusing on some of these modifiable aspects is key to a proactive approach to brain health.
Embrace Physical Activity
Performing regular physical activity is not just good for the body; but it is also vital for your brain. Working out physically helps in enhancing the blood flow in the brain section. This further delivers essential nutrients and oxygen. It can also lower inflammation and helps in enhancing synaptic plasticity, crucial for memory and thinking.
There are various studies that have shown moderate intensity exercise, including brisk walking for 30 minutes five days a week. This can be beneficial in numerous ways for multiple health deals.
- You are to aim for at least 150 minutes of aerobic activity, which can be performed on a weekly basis. Brisk walking, cycling, swimming, or dancing can be some of the activities that can help.
- Make sure to include strength training a couple of times a week which helps in supporting that overall health.
- Find activities that you enjoy which make exercise a sustainable part of your routine.
Nourish The Brain with a Healthy Diet
What you eat can directly impact your brain health. The Mediterranean diet, which is rich in fruits, vegetables, whole grains, nuts, and healthy fats. They have all been widely studied for their potential in lowering the risk of cognitive decline.
- Focus on whole, unprocessed foods: Make sure you include plenty of fruits, vegetables, pulses (like peas, beans, lentils), and nuts and seeds in the daily meals. They are to provide antioxidants which can further protect those brain cells.
- Choose whole grains:
You are to opt for brown rice, wholemeal bread, and wholewheat pasta right over those refined grains.
- Limit intake of red and processed meats:
You are to reduce consumption of lamb, beef, sausages, and bacon.
- Eat fish regularly: Oily fishlike salmon and mackerel, are known to be rich in omega-3 fatty acids. They are important for brain function.
- Use healthy fats:
Make sure you cook your regular meals with vegetable and plant oils including olive oil and rapeseed oil. On the other hand, avoid inclusion of solid fats including butter and ghee.
- Moderate use of sugar and salt can be considered:
Limit sugary treats and make sure to keep the daily salt consumption right below 6 grams (which can be approx. about a teaspoon).
- Mindful alcohol intake:
If you drink alcohol, just do it sensibly in moderation and ideally restrict its use to meals only.
Prioritize Quality Sleep
Sleeping is a critical time for the brain to repair and clear out waste products. This includes amyloid proteins, which are linked to Alzheimer’s. Following poor sleep quality or insufficient sleep can enhance the deposition of such proteins.
- You are to aim for approx. 7 to 9 hours each night of restorative sleep.
- Establish regular sleep schedules:
Carefully go to bed and wake up around the same time each day, may it be on weekends too.
- Create a relaxing bedtime routine:
Simply create a soothing aura. Dim the lights, avoid screens right before bedtime, and engage in calming activities including reading or performing meditation.
- Address sleep disorders:
In case you suspect to have some sort of sleep apnea or other sleep disturbances, consult a doctor.
Challenge The Mind and Stay Cognitively Active
Keeping the brain active throughout life can help in building cognitive reserve. This an enable the brain to better withstand the changes that are associated with Alzheimer’s Disease.
- Learn new things: Take up some extra classes, learn a new language, your favourite musical instrument, or follow a new hobby.
- Engage in activities including mental stimulation: Solve some crossword puzzles, jigsaw puzzles, numbered sudoku, or play exciting board games and card games.
- Read regularly: Act of reading can also help in exposing the brain to new information and this shall encourage critical thinking too.
- Volunteer or take up some new responsibilities: Some of these activities usually might need learning and problem-solving skills to develop.
Stay Socially Connected
Being a part of social interaction can be considered as a powerful brain exercise. While engaging with others, active listening, and thinking, all of this can stimulate brain activity. There is various research that suggests frequent social engagement which can delay those onsets of dementia.
- Connect with friends and family: Performing regularly meet up, call, or email your loved ones in intervals.
- Join clubs or groups: Participate in various activities which shall align your interests, whether it is a book club, some sports team, or simply volunteering a group.
- Engage in community activities: Attend some local events, workshops, or religious services.
Manage Chronic Health Conditions
Several medical conditions can affect heart health, and it can also enhance the risk of Alzheimer’s disease. Hence, effectively managing such issues can significantly lower your risk.
- High Blood Pressure (the condition is termed Hypertension): Uncontrolled high blood pressure can damage some of the blood vessels in the brain. This shall go as per the impairing blood flow. Performing regular check-up of the pressure and to follow the doctor’s recommendations to manage it.
- Diabetes: Levels related to high blood sugar harm the blood vessels and nerve cells at the same time. This can be about having diabetes, on managing the blood sugar through diet, exercise, and medication is crucial.
- High Cholesterol: High levels of cholesterol can be directly linked to an enhanced risk factor. Work with the doctor which helps in sustaining healthy cholesterol levels.
- Hearing Loss: Untreated conditions such as hearing loss which have been identified as a significant risk factor for dementia termed condition. This might further force the brain to work harder. On the other side it diverts the resources from other cognitive functions, it can also lead to social isolation at a larger scale. Address hearing loss with appropriate interventions including hearing aids.
- Protect The Head: Getting affected with carious head injuries can enhance the risk of dementia in individuals. You are to wear seat belts, use helmets while performing sports, and are to take proper precautions to prevent falls.
The Role of Genetic Testing To Prevent Alzheimer’s Disease
Understanding genetic makeup can provide valuable insights into the predisposition to Alzheimer’s disease. While genetics are not the sole determinant, they are to play a significant role for individuals at times.
What is Genetic Testing for Alzheimer’s Disease?
Genetic testing for Alzheimer’s Disease typically involves analysing specific genes that are well associated with the disease. Some of the most tested gene is APOE (apolipoprotein E).
- APOE e2: This variant is the least common and it reduces the risk of Alzheimer’s disease from occurring regularly.
- APOE e3: This is the most common variant and might not occur to affect the risk of this disease.
- APOE e4: This variant enhances the risk of evolving late-onset Alzheimer’s. Having one copy of APOE e4 can simply double or triple those notable risks. This goes while having two copies as it can enhance the risk by 8 to 12 times.
For a very small number of people with early-onset Alzheimer’s (which can be about the symptoms appearing between ages 30 and 60), specific alteration in some other genes, like APP, PSEN1, and PSEN2, are certain to cause the disease.
Opting for Genetic Testing For Alzheimer’s Disease From LifeCode
Alzheimer’s disease prevention is about empowering oneself with knowledge and taking proactive steps for a healthier brain. By embracing a brain-healthy lifestyle, managing chronic conditions, and understanding the genetic risk, one can significantly lower the chances of developing certain challenging diseases.
It is crucial to understand that a positive result for a risk gene named APOE e4 does not mean you might develop Alzheimer’s disease. Many people with one or even two copies of APOE e4 never come across such disease, while others without these variants do.
Genetic testing for those late-onset Alzheimer’s is highly not recommended for routine screening by most experts. This goes as it does not offer a definitive diagnosis or prognosis. However, this can be valuable for the below aspects:
- Understanding Personal Risk: For some of the individuals with a strong family history or those who are well concerned about the future cognitive health. Genetic testing can provide a clear picture of such risk factors.
- Informing Lifestyle Choices: Getting to know genetic predisposition can be a powerful motivator which shall be adopted with healthier lifestyle habits, potentially offsetting some of the genetic risk.
- Being a part of Research and Clinical Trials: For some individuals, genetic testing may not open doors to participating in clinical trials. This goes as well for those new Alzheimer’s treatments or several prevention strategies.
- Family Planning: In cases of early-onset Alzheimer’s having a strong hold of genetic link, testing like help can be a great deal for the families to understand the inheritance pattern.
For some disease-modifying treatments, including anti-amyloid therapies, genetic testing for Alzheimer is becoming increasingly important. Carrying one or more APOE e4 variants may increase the risk of side effects from these treatments.
If you’re thinking about your brain health, LifeCode is here to support you in every way.
Book a genetic consultation to go over your personal risk factors and find out if genetic testing is the right step for you. The experts at LifeCode provide personalized guidance and care to help you make informed choices.
- Order a genetic testing kit (swab test) today from LifeCode and gain valuable insights into genetic predisposition for Alzheimer’s disease from the comfort of your home.

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Education: Bachelor of Pharmacy (B.Pharm) from the Tata Institute of Social Sciences (TISS), Mumbai Experience: Agarwal is a seasoned pharmacist with over 7 years of experience in the pharmaceutical field. She has worked in various settings, including hospital pharmacies and community clinics, where she has excelled in medication management, patient counseling, and clinical support. Agarwal is known for her expertise in drug therapy optimization and patient safety. In addition to her practical experience, she contributes to health journalism, focusing on pharmaceutical advancements and health policy, and is involved in research projects aimed at improving medication practices and health outcomes. is known for her expertise in drug therapy optimization and patient safety. In addition to her practical experience, she contributes to health journalism, focusing on pharmaceutical advancements and health policy, and is involved in research projects aimed at improving medication practices and health outcomes.