Autoimmune Disease Panel

Auto Immune

Auto immune is a group of complex issues in which the body’s immune system mistakenly attacks its tissues. This shall all lead to inflammation, tissue damage, and dysfunction in various organs and systems. Such issues can all affect individuals of all ages and genders and this might have a significant impact on quality of life if left untreated.

What are Auto Immune Conditions?

Auto Immune condition occur when the immune system, which normally protects the body from harmful pathogens, mistakenly targets healthy cells and some of the tissues. Such immune response leads to inflammation and damage to various organs and some of the systems. This shall all depend on the specific auto immune condition. There are approx. 80 recognized auto immune diseases, like systemic lupus erythematosus (SLE), rheumatoid arthritis, multiple sclerosis, type 1 diabetes, and inflammatory bowel disease (IBD).

Causes of Auto immune Diseases:

The exact cause of some of the auto immune condition is not fully understood, but several factors may contribute to their development, including:

  • Genetic Factors: Certain genes may predispose individuals to auto immune diseases, making them more susceptible to developing these conditions.
  • Environmental Triggers: Environmental factors such as infections, toxins, dietary factors, and stress may trigger or exacerbate auto immune responses in genetically susceptible individuals.
  • Hormonal Factors: Hormonal changes, particularly in women, may influence the onset and severity of auto immune diseases. Many auto immune diseases, such as SLE and thyroid disorders, are more common in women than men.
  • Dysregulation of the Immune System: Dysfunction in the immune system, such as impaired regulation of immune cells or abnormal production of autoantibodies. This might further contribute to the development of auto immune diseases.

Common Symptoms of Auto immune Diseases:

The symptoms of auto immune diseases vary depending on the specific condition and the organs or systems affected. However, common symptoms may include:

  • Fatigue and Malaise: Persistent fatigue, weakness, and a general feeling of unwellness are common symptoms experienced by individuals with auto immune diseases.
  • Joint Pain and Swelling: Joint pain, stiffness, and swelling are characteristic symptoms of auto immune diseases such as rheumatoid arthritis and systemic lupus erythematosus.
  • Skin Rashes and Lesions: Skin manifestations, including rashes, redness, itching, and lesions, may occur in auto immune diseases such as psoriasis, dermatomyositis, and SLE.
  • Gastrointestinal Symptoms: Digestive symptoms like abdominal pain, diarrhea, constipation, and bloating may occur in auto immune conditions like inflammatory bowel disease (IBD) and celiac disease.
  • Neurological Symptoms: Auto immune diseases affecting the nervous system, such as multiple sclerosis and Guillain-Barré syndrome. This may cause symptoms such as numbness, tingling, weakness, and difficulty with coordination and balance.

Diagnosis of Auto immune Condition:

Diagnosing auto immune issues can be challenging due to the wide range of symptoms and the overlap with other conditions. Diagnostic tests may include:

  • Blood Tests: Blood tests may be performed to detect specific autoantibodies, inflammatory markers, and abnormalities in blood cell counts.
  • Imaging Studies: Imaging tests such as X-rays, ultrasounds, computed tomography (CT) scans, and magnetic resonance imaging (MRI) may be used to assess organ damage and inflammation.
  • Biopsy: A tissue biopsy may be performed to examine samples of affected tissues or organs under a microscope for signs of inflammation, damage, or abnormal cell growth.

Treatment Options for Auto immune Diseases:

Treatment for auto immune diseases aims to control symptoms, reduce inflammation, and suppress abnormal immune responses. Treatment options may include:

  • Medications: Various medications may be prescribed to manage symptoms and slow disease progression, including nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, disease-modifying antirheumatic drugs (DMARDs), immunosuppressants, and biologic therapies.
  • Lifestyle Modifications: Lifestyle changes such as regular exercise, a balanced diet, stress management techniques, and adequate rest may help support overall health and well-being in individuals with auto immune diseases.
  • Physical Therapy: Physical therapy and rehabilitation programs may help improve joint mobility, strength, and function in individuals with auto immune diseases affecting the musculoskeletal system.
  • Supportive Therapies: Complementary and alternative therapies such as acupuncture, massage therapy, and relaxation techniques may provide symptomatic relief and improve the quality of life for some individuals with auto immune diseases.

Auto immune diseases are complex conditions characterized by dysregulation of the immune system and inflammation in various organs and systems. While the exact cause of auto immune diseases remains unclear, genetic, environmental, hormonal, and immune factors are believed to play a role in their development.
Recognizing the symptoms of auto immune diseases and seeking timely medical evaluation and treatment are essential for managing symptoms, preventing complications, and improving the quality of life for individuals affected by these conditions.
At LifeCode Healthcare, we are committed to providing comprehensive care and support for individuals with auto immune diseases, helping them navigate their journey to better health and well-being.
If you or someone you know is experiencing symptoms of an auto immune disease, please don’t hesitate to contact us for evaluation and personalized treatment recommendations.

Categories Conditions Observed
AllergiesAllergic Asthma
 Allergic Rhinitis
 Allergies in General
 Allergy to Nuts
 Allergy to Pets
 Allergy to Shrimp
 Allergy to mites
 Allergy to pollen
 Asthma
 Atopic Dermatitis
 Cockroach allergy
 Cold-induced hives
 Contact dermatitis
 Eczema
 Egg White Allergy
 Grass allergy
 Histamine Intolerance
 IgE
 Mast Cell Activation Syndrome (MCAS)
 Milk Allergy
 Peach Allergy
 Peanut Allergy
  
CancerThyroid Neoplasm
  
CardiovascularProthrombin (G20210A Mutation)
  
Cardiovascular and CerebrovascularPhospholipase Cg2 Defect
  
CellsAutophagy
  
DiabetesEarly Type 2 Diabetes
 MODY Type 1 Diabetes
 MODY Type 2 Diabetes
 MODY Type 3 Diabetes
 MODY Type 4 Diabetes
 MODY Type 5 Diabetes
 MODY Type 6 Diabetes
 MODY Type Diabetes
 Type 1 Diabetes
 Type 2 diabetes
  
Digestive systemHirschsprung’s Disease (HD)
 Permeable Intestine Syndrome
 Primary Biliary Cirrhosis (CBP)
 Ulcerative Colitis
  
Endocrine systemAutoimmune Thyroid Disease
 Hashimoto’s Thyroiditis
 Hashimoto’s Thyroiditis (in children)
 Hyperparathyroidism
 Hyperthyroidism
 Hypothyroidism
 Hypothyroidism (Goiter)
 T3
 Thyroid Orbitopathy (OT)
 Thyroid dyshormonogenesis
 Thyrotoxicosis
  
Genetic diseasesFamilial Amyloidotic Polyneuropathy (FAP)
 Family Mediterranean Fever
 Hereditary angioedema
 Hyperimmunoglobulin E (Hyper IgE) Syndrome
 Rasopathies
 Selective IgA Deficiency
  
Hematologic systemActivated partial thromboplastin time (aPTT)
 Alpha-Defensins Levels
 Hemolytic Anemia
 High ferritin (in men)
 Post-Transfusion Purpura (PPT)
 Tendency to have Increased Eosinophils in Contact with Allergens
 Thrombophilia (Factor V – Protein C)
  
HormoneChange of Timo
 Reduction of Thyroid Hormonal Metabolism
 TSH
 Thyroid Function
 Thyroid Hormone Metabolism (T3: T4 Reduced Ratio)
  
Immune systemAcquired Immune Response
 Ankylosing spondylitis
 Anti-Beta-2-Glycoprotein Antibody
 Anti-DNA Antibody
 Anticardiolipin Antib.
 Antiphospholipid Antibody Syndrome
 Antithrombin Deficiency
 Autoimmune Lymphoproliferative Syndrome (ALPS)
 B Lymphocyte Deficiency
 C3 (immune) deficiency
 Chronic Granulomatous Disease (CGD)
 Combined immunodeficiency due to magnesium deficiency (XMEN)
 Common Variable Immunodeficiency – type 1
 Common Variable Immunodeficiency – type 2
 Common Variable Immunodeficiency – type 8
 Crohn’s disease
 Defect in Thyroid Hormonogenesis
 Dermatomyositis
 Factor V Leiden Mutation
 Familial hemophagocytic lymphohistiocytosis (HLH)
 Graves’ Disease
 Guillain-Barré Syndrome
 HLA-DQ2.2
 HLA-DQ2.5
 HLA-DQ4
 HLA-DQ7
 HLA-DQ8
 Herpes
 Immunodeficiency with Hyper IgM – type 1
 Increased Susceptibility to Contracting HIV-1
 Lichen Planus
 Lupus
 Lupus anticoagulant
 Lymphedema
 MYD88 deficiency
 Mannose Binding Protein Deficiency
 Mutation of the SERPINE1 Gene (PAI-1)
 Myeloperoxidase Deficiency
 Neurosarcoidosis
 Polyglandular deficiency syndromes
 Primary Sclerosing Cholangitis
 Prolactin Promoter Polymorphism
 Protein C Deficiency
 Protein S Deficiency
 Psoriasis
 Psoriatic arthritis
 Risk of Decreased Metabolism of Thyroid Hormones
 Severe Combined Immunodeficiency Syndrome
 Severe Combined Immunodeficiency with Sensitivity to Ionizing Radiation
 Severe Congenital Neutropenia
 Severe Congenital Neutropenia and Cyclic Neutropenia
 T Lymphocyte Deficiency
 Type 2 X-linked Lymphoproliferative Syndrome
 Wegener’s granulomatosis
 X-Linkerd Lymphoproliferative (XLP) Syndrome
 X-linked Lymphoproliferative Syndrome (XLP)
  
InflammationsBehçet’s Disease
 Frontal Fibrosing Alopecia
 Idiopathic inflammatory myopathy
 Inflammatory Bowel Disease (IBD)
 Polymyositis
 Presence of the HLA-B27 Allele
 Sarcoidosis
 Scleroderma
 Sjogren’s Syndrome
  
MetabolicCeliac disease
 Gluten Intolerance
 Glycation
 Greater Insulin Sensitivity with Physical Exercise
 Lactose intolerance
  
Metabolic disordersFetuin-A
  
MethylationMTHFR 1298 mutation (rs1801131)
 MTHFR 677 mutation (rs1801133)
  
Muscular systemMyasthenia Grave
  
Neurodegenerative diseasesCharcot-Marie Disease
 Louis-Bar Syndrome (Ataxia Telangiectasia)
 Multiple sclerosis
 Systemic Sclerosis
  
Respiratory systemChronic obstructive pulmonary disease
  
Skeletal system (bones)Arthritis
 Carpal tunnel syndrome
 Osteoarthritis
 Osteoporosis
 Rheumatoid arthritis
 Risk of amputation in case of diabetic foot ulcer
  
SkinAlopecia Areata
 Generalized Vitiligo
 Rosacea
 Vitiligo
  
Urinary systemMembranoproliferative Glomerulonephritis (GNMP)
 Nephrotic syndrome
  
Vision (Ophthalmology)Diabetic retinopathy

What types of autoimmune diseases can be detected through genetic testing?

Genetic testing can detect predispositions to a range of autoimmune diseases, including rheumatoid arthritis, type 1 diabetes, lupus, multiple sclerosis, celiac disease, and others. 

Can genetic testing accurately predict the risk of developing autoimmune diseases?

Genetic testing can provide insight into an individual’s genetic predisposition to certain autoimmune diseases, but it cannot definitively predict whether someone will develop the condition.

Are there specific genetic markers associated with certain autoimmune diseases?

Yes, researchers have identified specific genetic markers, such as certain HLA alleles, that are associated with increased susceptibility to certain autoimmune diseases. 

What are the benefits of undergoing genetic testing for autoimmune diseases?

Genetic testing can help individuals understand their risk factors, make informed decisions about their health, and potentially identify opportunities for early intervention or preventive measures. 

Are there any limitations or risks associated with genetic testing for autoimmune diseases?

Limitations include the inability to predict with certainty whether an individual will develop a particular autoimmune disease, as well as the potential for psychological stress associated with learning about genetic predispositions. 

How do lifestyle factors interact with genetic predispositions identified through testing for autoimmune diseases?

Lifestyle factors such as diet, exercise, stress management, and environmental exposures can interact with genetic predispositions to influence the development and progression of autoimmune diseases. Adopting a healthy lifestyle may help mitigate some of the risks associated with genetic predispositions.  

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