Auto Immune
Auto immune is a group of complex issues in which the body’s immune system mistakenly attacks its tissues. This shall all lead to inflammation, tissue damage, and dysfunction in various organs and systems. Such issues can all affect individuals of all ages and genders and this might have a significant impact on quality of life if left untreated.
What are Auto Immune Conditions?
Auto Immune condition occur when the immune system, which normally protects the body from harmful pathogens, mistakenly targets healthy cells and some of the tissues. Such immune response leads to inflammation and damage to various organs and some of the systems. This shall all depend on the specific auto immune condition. There are approx. 80 recognized auto immune diseases, like systemic lupus erythematosus (SLE), rheumatoid arthritis, multiple sclerosis, type 1 diabetes, and inflammatory bowel disease (IBD).
Causes of Auto immune Diseases:
The exact cause of some of the auto immune condition is not fully understood, but several factors may contribute to their development, including:
- Genetic Factors: Certain genes may predispose individuals to auto immune diseases, making them more susceptible to developing these conditions.
- Environmental Triggers: Environmental factors such as infections, toxins, dietary factors, and stress may trigger or exacerbate auto immune responses in genetically susceptible individuals.
- Hormonal Factors: Hormonal changes, particularly in women, may influence the onset and severity of auto immune diseases. Many auto immune diseases, such as SLE and thyroid disorders, are more common in women than men.
- Dysregulation of the Immune System: Dysfunction in the immune system, such as impaired regulation of immune cells or abnormal production of autoantibodies. This might further contribute to the development of auto immune diseases.
Common Symptoms of Auto immune Diseases:
The symptoms of auto immune diseases vary depending on the specific condition and the organs or systems affected. However, common symptoms may include:
- Fatigue and Malaise: Persistent fatigue, weakness, and a general feeling of unwellness are common symptoms experienced by individuals with auto immune diseases.
- Joint Pain and Swelling: Joint pain, stiffness, and swelling are characteristic symptoms of auto immune diseases such as rheumatoid arthritis and systemic lupus erythematosus.
- Skin Rashes and Lesions: Skin manifestations, including rashes, redness, itching, and lesions, may occur in auto immune diseases such as psoriasis, dermatomyositis, and SLE.
- Gastrointestinal Symptoms: Digestive symptoms like abdominal pain, diarrhea, constipation, and bloating may occur in auto immune conditions like inflammatory bowel disease (IBD) and celiac disease.
- Neurological Symptoms: Auto immune diseases affecting the nervous system, such as multiple sclerosis and Guillain-Barré syndrome. This may cause symptoms such as numbness, tingling, weakness, and difficulty with coordination and balance.
Diagnosis of Auto immune Condition:
Diagnosing auto immune issues can be challenging due to the wide range of symptoms and the overlap with other conditions. Diagnostic tests may include:
- Blood Tests: Blood tests may be performed to detect specific autoantibodies, inflammatory markers, and abnormalities in blood cell counts.
- Imaging Studies: Imaging tests such as X-rays, ultrasounds, computed tomography (CT) scans, and magnetic resonance imaging (MRI) may be used to assess organ damage and inflammation.
- Biopsy: A tissue biopsy may be performed to examine samples of affected tissues or organs under a microscope for signs of inflammation, damage, or abnormal cell growth.
Treatment Options for Auto immune Diseases:
Treatment for auto immune diseases aims to control symptoms, reduce inflammation, and suppress abnormal immune responses. Treatment options may include:
- Medications: Various medications may be prescribed to manage symptoms and slow disease progression, including nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, disease-modifying antirheumatic drugs (DMARDs), immunosuppressants, and biologic therapies.
- Lifestyle Modifications: Lifestyle changes such as regular exercise, a balanced diet, stress management techniques, and adequate rest may help support overall health and well-being in individuals with auto immune diseases.
- Physical Therapy: Physical therapy and rehabilitation programs may help improve joint mobility, strength, and function in individuals with auto immune diseases affecting the musculoskeletal system.
- Supportive Therapies: Complementary and alternative therapies such as acupuncture, massage therapy, and relaxation techniques may provide symptomatic relief and improve the quality of life for some individuals with auto immune diseases.
Auto immune diseases are complex conditions characterized by dysregulation of the immune system and inflammation in various organs and systems. While the exact cause of auto immune diseases remains unclear, genetic, environmental, hormonal, and immune factors are believed to play a role in their development.
Recognizing the symptoms of auto immune diseases and seeking timely medical evaluation and treatment are essential for managing symptoms, preventing complications, and improving the quality of life for individuals affected by these conditions.
At LifeCode Healthcare, we are committed to providing comprehensive care and support for individuals with auto immune diseases, helping them navigate their journey to better health and well-being.
If you or someone you know is experiencing symptoms of an auto immune disease, please don’t hesitate to contact us for evaluation and personalized treatment recommendations.
Categories | Conditions Observed |
---|---|
Allergies | Allergic Asthma |
Allergic Rhinitis | |
Allergies in General | |
Allergy to Nuts | |
Allergy to Pets | |
Allergy to Shrimp | |
Allergy to mites | |
Allergy to pollen | |
Asthma | |
Atopic Dermatitis | |
Cockroach allergy | |
Cold-induced hives | |
Contact dermatitis | |
Eczema | |
Egg White Allergy | |
Grass allergy | |
Histamine Intolerance | |
IgE | |
Mast Cell Activation Syndrome (MCAS) | |
Milk Allergy | |
Peach Allergy | |
Peanut Allergy | |
Cancer | Thyroid Neoplasm |
Cardiovascular | Prothrombin (G20210A Mutation) |
Cardiovascular and Cerebrovascular | Phospholipase Cg2 Defect |
Cells | Autophagy |
Diabetes | Early Type 2 Diabetes |
MODY Type 1 Diabetes | |
MODY Type 2 Diabetes | |
MODY Type 3 Diabetes | |
MODY Type 4 Diabetes | |
MODY Type 5 Diabetes | |
MODY Type 6 Diabetes | |
MODY Type Diabetes | |
Type 1 Diabetes | |
Type 2 diabetes | |
Digestive system | Hirschsprung’s Disease (HD) |
Permeable Intestine Syndrome | |
Primary Biliary Cirrhosis (CBP) | |
Ulcerative Colitis | |
Endocrine system | Autoimmune Thyroid Disease |
Hashimoto’s Thyroiditis | |
Hashimoto’s Thyroiditis (in children) | |
Hyperparathyroidism | |
Hyperthyroidism | |
Hypothyroidism | |
Hypothyroidism (Goiter) | |
T3 | |
Thyroid Orbitopathy (OT) | |
Thyroid dyshormonogenesis | |
Thyrotoxicosis | |
Genetic diseases | Familial Amyloidotic Polyneuropathy (FAP) |
Family Mediterranean Fever | |
Hereditary angioedema | |
Hyperimmunoglobulin E (Hyper IgE) Syndrome | |
Rasopathies | |
Selective IgA Deficiency | |
Hematologic system | Activated partial thromboplastin time (aPTT) |
Alpha-Defensins Levels | |
Hemolytic Anemia | |
High ferritin (in men) | |
Post-Transfusion Purpura (PPT) | |
Tendency to have Increased Eosinophils in Contact with Allergens | |
Thrombophilia (Factor V – Protein C) | |
Hormone | Change of Timo |
Reduction of Thyroid Hormonal Metabolism | |
TSH | |
Thyroid Function | |
Thyroid Hormone Metabolism (T3: T4 Reduced Ratio) | |
Immune system | Acquired Immune Response |
Ankylosing spondylitis | |
Anti-Beta-2-Glycoprotein Antibody | |
Anti-DNA Antibody | |
Anticardiolipin Antib. | |
Antiphospholipid Antibody Syndrome | |
Antithrombin Deficiency | |
Autoimmune Lymphoproliferative Syndrome (ALPS) | |
B Lymphocyte Deficiency | |
C3 (immune) deficiency | |
Chronic Granulomatous Disease (CGD) | |
Combined immunodeficiency due to magnesium deficiency (XMEN) | |
Common Variable Immunodeficiency – type 1 | |
Common Variable Immunodeficiency – type 2 | |
Common Variable Immunodeficiency – type 8 | |
Crohn’s disease | |
Defect in Thyroid Hormonogenesis | |
Dermatomyositis | |
Factor V Leiden Mutation | |
Familial hemophagocytic lymphohistiocytosis (HLH) | |
Graves’ Disease | |
Guillain-Barré Syndrome | |
HLA-DQ2.2 | |
HLA-DQ2.5 | |
HLA-DQ4 | |
HLA-DQ7 | |
HLA-DQ8 | |
Herpes | |
Immunodeficiency with Hyper IgM – type 1 | |
Increased Susceptibility to Contracting HIV-1 | |
Lichen Planus | |
Lupus | |
Lupus anticoagulant | |
Lymphedema | |
MYD88 deficiency | |
Mannose Binding Protein Deficiency | |
Mutation of the SERPINE1 Gene (PAI-1) | |
Myeloperoxidase Deficiency | |
Neurosarcoidosis | |
Polyglandular deficiency syndromes | |
Primary Sclerosing Cholangitis | |
Prolactin Promoter Polymorphism | |
Protein C Deficiency | |
Protein S Deficiency | |
Psoriasis | |
Psoriatic arthritis | |
Risk of Decreased Metabolism of Thyroid Hormones | |
Severe Combined Immunodeficiency Syndrome | |
Severe Combined Immunodeficiency with Sensitivity to Ionizing Radiation | |
Severe Congenital Neutropenia | |
Severe Congenital Neutropenia and Cyclic Neutropenia | |
T Lymphocyte Deficiency | |
Type 2 X-linked Lymphoproliferative Syndrome | |
Wegener’s granulomatosis | |
X-Linkerd Lymphoproliferative (XLP) Syndrome | |
X-linked Lymphoproliferative Syndrome (XLP) | |
Inflammations | Behçet’s Disease |
Frontal Fibrosing Alopecia | |
Idiopathic inflammatory myopathy | |
Inflammatory Bowel Disease (IBD) | |
Polymyositis | |
Presence of the HLA-B27 Allele | |
Sarcoidosis | |
Scleroderma | |
Sjogren’s Syndrome | |
Metabolic | Celiac disease |
Gluten Intolerance | |
Glycation | |
Greater Insulin Sensitivity with Physical Exercise | |
Lactose intolerance | |
Metabolic disorders | Fetuin-A |
Methylation | MTHFR 1298 mutation (rs1801131) |
MTHFR 677 mutation (rs1801133) | |
Muscular system | Myasthenia Grave |
Neurodegenerative diseases | Charcot-Marie Disease |
Louis-Bar Syndrome (Ataxia Telangiectasia) | |
Multiple sclerosis | |
Systemic Sclerosis | |
Respiratory system | Chronic obstructive pulmonary disease |
Skeletal system (bones) | Arthritis |
Carpal tunnel syndrome | |
Osteoarthritis | |
Osteoporosis | |
Rheumatoid arthritis | |
Risk of amputation in case of diabetic foot ulcer | |
Skin | Alopecia Areata |
Generalized Vitiligo | |
Rosacea | |
Vitiligo | |
Urinary system | Membranoproliferative Glomerulonephritis (GNMP) |
Nephrotic syndrome | |
Vision (Ophthalmology) | Diabetic retinopathy |
What types of autoimmune diseases can be detected through genetic testing?
Genetic testing can detect predispositions to a range of autoimmune diseases, including rheumatoid arthritis, type 1 diabetes, lupus, multiple sclerosis, celiac disease, and others.
Can genetic testing accurately predict the risk of developing autoimmune diseases?
Genetic testing can provide insight into an individual’s genetic predisposition to certain autoimmune diseases, but it cannot definitively predict whether someone will develop the condition.
Are there specific genetic markers associated with certain autoimmune diseases?
Yes, researchers have identified specific genetic markers, such as certain HLA alleles, that are associated with increased susceptibility to certain autoimmune diseases.
What are the benefits of undergoing genetic testing for autoimmune diseases?
Genetic testing can help individuals understand their risk factors, make informed decisions about their health, and potentially identify opportunities for early intervention or preventive measures.
Are there any limitations or risks associated with genetic testing for autoimmune diseases?
Limitations include the inability to predict with certainty whether an individual will develop a particular autoimmune disease, as well as the potential for psychological stress associated with learning about genetic predispositions.
How do lifestyle factors interact with genetic predispositions identified through testing for autoimmune diseases?
Lifestyle factors such as diet, exercise, stress management, and environmental exposures can interact with genetic predispositions to influence the development and progression of autoimmune diseases. Adopting a healthy lifestyle may help mitigate some of the risks associated with genetic predispositions.